“We’re one step closer to cancer prevention and detection,” says Gybels. “We already have a wealth of knowledge about how these Selenoproteins function in the testes, but this is the first time anybody has identified a protein that is linked to cancer, so this provides us with new avenues for determining how these proteins work in humans,” says Dr.
The researchers were intrigued by this family of proteins because they had been shown to protect males against oxidative stress that leads to cancer. The research team identified C3ORF1 from a group of proteins called Selenoproteins, known to be present in sperm. The researchers found C3ORF1, which is a cancer trigger in mice, to be a novel protein that is elevated in cancer patients who have liver cancer and melanoma. Gybels says SELENOI would not have been detected without the 10 years of research into the genetic causes of cancer. Gybels of the Alberta Heritage Foundation for Medical Research (AHFMR). “Our findings are important because we now know the protein product of this gene is a novel protein called SELENOI and it is actually elevated in the blood of a large percentage of cancer patients,” says Dr.
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